Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104976 | 0.97 | KDM4E (0.36) | KDM4EPOLBALDH1A1HTTLMNA | |
| SCHEMBL8104780 | 0.84 | P2RX7 (0.45) | ALDH1A1SMN1; SMN2MEN1KMT2AP2RX7 | |
| SCHEMBL8104812 | 0.80 | HSP90AA1 (0.37) | KDM4EALDH1A1MEN1HTTKMT2A | |
| SCHEMBL7965604 | 0.69 | P2RX7 (0.71) | P2RX7EPHX2 | |
| SCHEMBL6937092 | 0.68 | CNR2 (0.37) | MEN1KMT2AP2RX7EPHX2 | |
| SCHEMBL7956634 | 0.66 | P2RX7 (0.72) | P2RX7EPHX2 | |
| SCHEMBL1799261 | 0.60 | PDK2 (0.55) | KDM4EPOLBALDH1A1NSD2SMN1; SMN2 | |
| SCHEMBL6939407 | 0.59 | P2RX7 (0.72) | P2RX7EPHX2 | |
| Hydrochloric Acid SCHEMBL6943149 | 0.59 | P2RX7 (0.71) | P2RX7EPHX2 | |
| SCHEMBL5075726 | 0.59 | DRD2 (0.61) | KDM4EALDH1A1SMN1; SMN2MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029660-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |