Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104812 | 0.87 | HSP90AA1 (0.37) | P2RX7CNR2MEN1KMT2AFAAH | |
| SCHEMBL8104976 | 0.85 | KDM4E (0.36) | P2RX7EPHX2ALDH1A1 | |
| SCHEMBL8095608 | 0.84 | KDM4E (0.38) | P2RX7MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL6937092 | 0.81 | CNR2 (0.37) | P2RX7CNR2MEN1KMT2AFAAH | |
| SCHEMBL5805025 | 0.63 | P2RX7 (0.47) | P2RX7SIGMAR1CNR2MEN1KMT2A | |
| SCHEMBL6860227 | 0.62 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2968543 | 0.62 | MTNR1A (0.44) | P2RX7MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL6939824 | 0.61 | P2RX7 (0.71) | P2RX7SIGMAR1CNR2MEN1KMT2A | |
| SCHEMBL11783904 | 0.61 | NPC1 (0.49) | P2RX7MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL6941692 | 0.60 | STS (0.34) | P2RX7CNR2MEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029660-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |