Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104780 | 0.87 | P2RX7 (0.45) | MEN1KMT2AALDH1A1P2RX7FAAH | |
| SCHEMBL8104976 | 0.81 | KDM4E (0.36) | KDM4EALDH1A1HPGDHTTP2RX7 | |
| SCHEMBL8095608 | 0.80 | KDM4E (0.38) | MEN1KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL6937092 | 0.73 | CNR2 (0.37) | MEN1KMT2AP2RX7FAAHCNR2 | |
| SCHEMBL6942683 | 0.65 | ALDH1A1 (0.40) | HSP90AA1GAAMAPTMEN1KMT2A | |
| SCHEMBL6941692 | 0.61 | STS (0.34) | MEN1KMT2AP2RX7CNR2EPHX2 | |
| SCHEMBL22186346 | 0.60 | LMNA (0.38) | MAPTALDH1A1ALOX12HTTCNR2 | |
| SCHEMBL6939404 | 0.59 | P2RX7 (0.72) | P2RX7 | |
| SCHEMBL3783963 | 0.59 | P2RX7 (0.36) | GAAP2RX7EPHX2 | |
| SCHEMBL6941696 | 0.58 | P2RX7 (0.40) | HSP90AA1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029660-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |