Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932106 | 0.88 | SLC9A1 (0.46) | SLC9A1POLB | |
| SCHEMBL6932510 | 0.87 | SLC9A1 (0.43) | SLC9A1HSD11B1 | |
| SCHEMBL6938965 | 0.86 | SLC9A1 (0.39) | SLC9A1POLBF2PRSS1PRSS2 | |
| SCHEMBL6932982 | 0.85 | POLB (0.41) | SLC9A1POLBF2PRSS1PRSS2 | |
| SCHEMBL6937336 | 0.85 | ALDH1A1 (0.44) | SLC9A1POLBF2PRSS1PRSS2 | |
| SCHEMBL6937615 | 0.84 | HPD (0.37) | SLC9A1HSD11B1 | |
| SCHEMBL6935486 | 0.84 | SLC9A1 (0.47) | SLC9A1 | |
| SCHEMBL8538237 | 0.84 | KIF18A (0.44) | SLC9A1POLBF2PRSS1PRSS2 | |
| SCHEMBL6932480 | 0.83 | HSP90AA1 (0.40) | SLC9A1 | |
| SCHEMBL7070825 | 0.80 | SLC9A1 (0.42) | SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |