Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | CHKA known ✓ | P35790 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11949311 | 0.99 | RAB9A (0.48) | NPC1RAB9APKMACHENPSR1 | |
| Hydrochloric Acid SCHEMBL1373732 | 0.97 | PKM (0.47) | NPC1RAB9APKMACHENPSR1 | |
| Bromide SCHEMBL555083 | 0.88 | CA12 (0.43) | NPC1RAB9APKM | |
| Bromide SCHEMBL31432631 | 0.86 | ALDH1A1 (0.49) | NPC1RAB9APKMACHENPSR1 | |
| Bromide SCHEMBL1375323 | 0.86 | PKM (0.44) | NPC1RAB9APKMACHENPSR1 | |
| SCHEMBL16809393 | 0.85 | ALDH1A1 (0.50) | NPC1RAB9APKMACHENPSR1 | |
| Bromide SCHEMBL15820807 | 0.79 | ACHE (0.48) | RAB9AACHENPSR1L3MBTL1SMN1; SMN2 | |
| SCHEMBL15836427 | 0.77 | ALDH1A1 (0.46) | RAB9AACHENPSR1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5307716 | 0.71 | ALDH1A1 (0.53) | RAB9AACHENPSR1L3MBTL1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7307884 | 0.70 | ALDH1A1 (0.56) | RAB9AACHENPSR1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539965-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | UNICHEM LAB LTD (IN) | 2021-01-20 | — | — | EP | disclosed |
| US-10829450-B2 | Process for the preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine | UNICHEM LABORATORIES LIMITED (IN) | 2020-11-10 | — | — | US | disclosed |
| EP-3539965-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | UNICHEM LABORATORIES LIMITED (IN) | 2019-09-18 | — | — | EP | disclosed |
| US-20180134661-A1 | Process for the Preparation of (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | UNICHEM LAB LTD (IN) | 2018-05-17 | — | — | US | disclosed |
| US-9951012-B2 | Process for the preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine | UNICHEM LABORATORIES LIMITED (IN) | 2018-04-24 | — | — | US | disclosed |
| US-20180037551-A1 | Process for the Preparation of (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | UNICHEM LAB LTD (IN) | 2018-02-08 | — | — | US | disclosed |
| US-9856261-B2 | Piperidine inhibitors of Janus kinase 3 | AUSPEX PHARMACEUTICALS, INC. (US) | 2018-01-02 | — | — | US | disclosed |
| US-20170240510-A1 | PROCESS FOR THE PREPARATION OF (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | UNICHEM LAB LTD (IN) | 2017-08-24 | — | — | US | disclosed |
| EP-3026052-A9 | PREPARATION OF DEUTERATED PIPERIDINE INHIBITORS OF JANUS KINASE 3 | Auspex Pharmaceuticals, Inc. (US) | 2016-12-07 | — | — | EP | disclosed |
| US-20160340361-A1 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | AUSPEX PHARMACEUTICALS, INC. | 2016-11-24 | — | — | US | disclosed |
| US-20130040974-A1 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | AUSPEX PHARMACEUTICALS, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-8309716-B2 | Pyrrolo[2,3-d]pyrimidine derivatives: their intermediates and synthesis | PFIZER INC. (US) | 2012-11-13 | — | — | US | disclosed |
| US-8299084-B2 | Piperidine inhibitors of Janus kinase 3 | AUSPEX PHARMACEUTICALS, INC. (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120259115-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES: THEIR INTERMEDIATES AND SYNTHESIS | PFIZER INC. (US) | 2012-10-11 | — | — | US | disclosed |
| US-8232394-B2 | Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis | PFIZER INC. (US) | 2012-07-31 | — | — | US | disclosed |
| EP-2421867-A2 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | Auspex Pharmaceuticals, Llc (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1913000-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES; THEIR INTERMEDIATES AND SYNTHESIS | PFIZER PROD INC (US) | 2012-01-11 | — | — | EP | disclosed |
| US-20110288297-A1 | Pyrrolo[2,3-d]Pyrimidine Derivatives; Their Intermediates and Synthesis | PFIZER, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| US-20100291026-A1 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| WO-2010123919-A2 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | AUSPEX PHARMACEUTICALS, LLC (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180037551-A1 | Process for the Preparation of (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | KDM4D, KDM4A, KDM4C | ACHE 687/4885CHKA 2709/4885NPC1 4424/4885 |
| US-20120259115-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES: THEIR INTERMEDIATES AND SYNTHESIS | DPYD, CPS1, TYMS | ACHE 4467/4885CHKA 3403/4885NPC1 4682/4885 |
| US-20180134661-A1 | Process for the Preparation of (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | KDM4D, KDM4A, KDM4C | ACHE 687/4885CHKA 2709/4885NPC1 4424/4885 |
| US-10829450-B2 | Process for the preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine | KDM4D, KDM4A, KDM4C | ACHE 687/4885CHKA 2709/4885NPC1 4424/4885 |
| US-20160340361-A1 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | JAK2, JAK3, PAK3 | ACHE 3892/4885CHKA 595/4885NPC1 3045/4885 |
| US-20130040974-A1 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | JAK2, JAK3, PAK3 | ACHE 3892/4885CHKA 595/4885NPC1 3045/4885 |
| US-20110288297-A1 | Pyrrolo[2,3-d]Pyrimidine Derivatives; Their Intermediates and Synthesis | DPYD, CPS1, TYMS | ACHE 4478/4885CHKA 3386/4885NPC1 4650/4885 |
| US-20170240510-A1 | PROCESS FOR THE PREPARATION OF (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE | KDM4D, KDM4A, KDM4C | ACHE 687/4885CHKA 2709/4885NPC1 4424/4885 |
| US-20100291026-A1 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | JAK2, JAK3, PAK3 | ACHE 3892/4885CHKA 595/4885NPC1 3045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.