Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP14 | P50281 | 2/20 | 0.35 |
| ▸ | MMP8 | P22894 | 3/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | MMP3 | P08254 | 2/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989546 | 0.83 | BMP1 (0.35) | MMP1MMP8MMP2MMP3METAP2 | |
| SCHEMBL6984786 | 0.81 | MMP2 (0.32) | MMP1MMP9MMP14MMP8ADAM17 | |
| Hydrochloric Acid SCHEMBL6986332 | 0.80 | MMP2 (0.32) | MMP1MMP9MMP14MMP8ADAM17 | |
| SCHEMBL6942689 | 0.80 | MMP1 (0.35) | MMP1MMP9MMP14MMP8ADAM17 | |
| SCHEMBL6982424 | 0.79 | BCHE (0.30) | BCHE | |
| SCHEMBL6982649 | 0.79 | ANPEP (0.40) | MMP1MMP8ADAM17MMP2MMP3 | |
| SCHEMBL6983030 | 0.76 | MMP1 (0.32) | MMP1MMP8MMP2MMP3MMP7 | |
| SCHEMBL6940029 | 0.74 | MMP1 (0.36) | MMP1MMP9MMP14MMP8ADAM17 | |
| SCHEMBL7812254 | 0.69 | PSEN1 (0.35) | MMP1MMP9MMP8MMP2MMP3 | |
| SCHEMBL6939924 | 0.69 | ADAM17 (0.40) | MMP1MMP9MMP14ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |