Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943584 | 0.84 | SMN1; SMN2 (0.35) | KMT2AALDH1A1POLBADAM17TP53 | |
| SCHEMBL6938021 | 0.83 | ALDH1A1 (0.35) | ALDH1A1POLBADAM17CCNA2CDK2 | |
| SCHEMBL6946107 | 0.83 | ADAM17 (0.38) | POLBADAM17 | |
| SCHEMBL6944200 | 0.81 | ADAM17 (0.45) | ALDH1A1ADAM17TP53HPGDTSHR | |
| SCHEMBL6947352 | 0.81 | ADAM17 (0.51) | KMT2AALDH1A1POLBADAM17GAA | |
| SCHEMBL6939991 | 0.80 | MMP1 (0.42) | KMT2AALDH1A1POLBADAM17GAA | |
| SCHEMBL6946852 | 0.80 | ADAM17 (0.40) | POLBADAM17CCNA2CDK2CCNA1 | |
| SCHEMBL6942897 | 0.79 | ADAM17 (0.40) | KMT2AALDH1A1ADAM17TP53HPGD | |
| SCHEMBL6942385 | 0.78 | ADAM17 (0.45) | KMT2AALDH1A1POLBADAM17SMN1; SMN2 | |
| SCHEMBL8099196 | 0.78 | ADAM17 (0.33) | POLBADAM17TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |