Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940732 | 1.00 | MTNR1A (0.54) | MTNR1AMTNR1BAPPSMPD1HDAC1 | |
| SCHEMBL6947411 | 0.85 | SIGMAR1 (0.54) | SMPD1SIGMAR1 | |
| SCHEMBL6947408 | 0.85 | SIGMAR1 (0.54) | SMPD1SIGMAR1 | |
| SCHEMBL7076864 | 0.84 | PPARA (0.42) | TRPV1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7076862 | 0.84 | PPARA (0.42) | TRPV1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6942961 | 0.83 | REN (0.44) | PDE4APDE4BPDE4CPDE4DSIGMAR1 | |
| SCHEMBL6942964 | 0.83 | REN (0.44) | PDE4APDE4BPDE4CPDE4DSIGMAR1 | |
| SCHEMBL6940652 | 0.82 | TUBB4A (0.54) | TRPV1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL6940648 | 0.82 | TUBB4A (0.54) | TRPV1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8889965 | 0.80 | APP (0.56) | MTNR1AMTNR1BAPPSMPD1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003103653-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE USING ARYL ALKANOIC ACID AMIDES | ELAN PHARMACEUTICALS, INC. (US) | 2003-12-18 | — | — | WO | disclosed |