Sugi Predict

Sugi Predict / Compounds / SCHEMBL695140

SCHEMBL695140

SCHEMBL695140

COc1c(Cl)ccc(-c2cc(N)c(Cl)c(C(=O)NOCC(C)C)n2)c1F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.37
▸ LMNA P02545 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ MEP1B Q16820 1/20 0.34
▸ SCN10A Q9Y5Y9 1/20 0.33
▸ ALPL P05186 2/20 0.33
▸ KLKB1 P03952 1/20 0.33
▸ PTGES O14684 2/20 0.33
▸ MAPK8 P45983 1/20 0.33
▸ MAPK9 P45984 1/20 0.33
▸ MAPK10 P53779 1/20 0.33
▸ PDCD1LG2 Q9BQ51 2/20 0.32
▸ CD274 Q9NZQ7 2/20 0.32
▸ HPGD P15428 1/20 0.32
▸ ROCK2 O75116 1/20 0.32
▸ ROCK1 Q13464 1/20 0.32
▸ PSMB5 P28074 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ SCN5A Q14524 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL694666 0.89 MEP1B (0.35) KDM4EMEP1BSCN10AALPLKLKB1
SCHEMBL694248 0.89 MEP1B (0.35) KDM4ELMNASMN1; SMN2MEP1BSCN10A
SCHEMBL693815 0.88 ALDH1A1 (0.35) KDM4ELMNASMN1; SMN2MEP1BSCN10A
SCHEMBL693563 0.88 MEP1B (0.33) KDM4EMEP1BSCN10AALPLKLKB1
SCHEMBL693573 0.87 ALDH1A1 (0.37) KDM4EMEP1BALPLKLKB1MAPK8
SCHEMBL693954 0.87 SCN10A (0.35) KDM4ELMNASMN1; SMN2MEP1BSCN10A
SCHEMBL693348 0.87 MEP1B (0.38) KDM4EMEP1BSCN10AALPLKLKB1
SCHEMBL28733112 0.87 ALDH1A1 (0.41) KDM4EMEP1BSCN10AALPLKLKB1
SCHEMBL693654 0.86 SMN1; SMN2 (0.37) KDM4ESMN1; SMN2MEP1BKLKB1ALDH1A1
SCHEMBL693569 0.86 ALPL (0.34) KDM4EMEP1BSCN10AALPLKLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 — — US claimed
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 — — US disclosed
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 — — US disclosed
EP-2421832-B1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2013-12-18 — — EP disclosed
US-20130324412-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2013-12-05 — — US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 — — US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 — — US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 — — US disclosed
EP-2421832-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS Dow AgroSciences LLC (US) 2012-02-29 — — EP disclosed
WO-2010099279-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 — — WO disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 — — US disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 — — US disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS HASPIN, NOTUM, CANX KDM4E 1195/4885LMNA 4390/4885SMN1; SMN2 2814/4885
US-20130324412-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS NPEPPS, DNPEP, HASPIN KDM4E 507/4885LMNA 3647/4885SMN1; SMN2 2484/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.