SCHEMBL69437

SCHEMBL69437

[c]1ccc(Nc2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 5/20 0.67
ALDH1A1 P00352 8/20 0.63
TDP1 Q9NUW8 7/20 0.63
ALOX12 P18054 4/20 0.63
L3MBTL1 Q9Y468 4/20 0.63
TSHR P16473 4/20 0.63
ALOX15 P16050 2/20 0.63
PTGS1 P23219 1/20 0.63
SLC6A2 P23975 1/20 0.63
MAPK1 P28482 1/20 0.63
PTGS2 P35354 1/20 0.63
HTR2B P41595 1/20 0.63
MAPT P10636 8/20 0.55
MEN1 O00255 5/20 0.55
KMT2A Q03164 5/20 0.55
AR P10275 1/20 0.55
CYP3A4 P08684 5/20 0.50
HPGD P15428 3/20 0.50
HTT P42858 2/20 0.50
CYP1A2 P05177 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9274501 0.97 ALDH1A1 (0.68) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
SCHEMBL12467721 0.88 HSD17B10 (0.44) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
SCHEMBL27826447 0.85 ALDH1A1 (0.52) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
Diphenylamine SCHEMBL8602771 0.85 HSD17B10 (0.92) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
SCHEMBL6414575 0.83 ALDH1A1 (0.67) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
N,N'-Diphenyl-P-Phenylenediamine SCHEMBL26929497 0.82 ALDH1A1 (0.93) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
Diphenylamine SCHEMBL11650896 0.82 HSD17B10 (0.86) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
Diphenylamine SCHEMBL8852775 0.82 HSD17B10 (0.86) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
Diphenylamine SCHEMBL3003404 0.82 HSD17B10 (1.00) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
Diphenylamine SCHEMBL1619083 0.82 HSD17B10 (1.00) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1227 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118344265-A Amide compound and preparation method and application thereof 河北大学 2024-07-16 CN claimed
EP-3778576-B1 2-CYANOPYRIMIDIN-4-YL CARBAMATE OR UREA DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME HANLIM PHARMACEUTICAL CO LTD (KR) 2024-04-17 EP claimed
CN-115400114-A Application of non-steroidal organic selenium compound in preparation of medicine for treating or preventing intestinal inflammation related diseases 辽宁大学 2022-11-29 CN claimed
CN-109880264-B High-strength flame-retardant plastic steel profile based on organic silicon modified polyvinyl chloride 河北艾森新材料科技有限公司 2021-10-22 CN claimed
CN-105980386-B Pyrazolo compounds and uses thereof 基因泰克公司 2021-08-13 CN claimed
US-20210047301-A1 2-CYANOPYRIMIDIN-4-YL CARBAMATE OR UREA DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME HANLIM PHARMACEUTICAL CO., LTD. (KR) 2021-02-18 US claimed
EP-3778576-A1 2-CYANOPYRIMIDIN-4-YL CARBAMATE OR UREA DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Hanlim Pharmaceutical Co., Ltd. (KR) 2021-02-17 EP claimed
CN-111956639-A Use of organic selenium compounds for treating diseases associated with neuroinflammation 辽宁大学 2020-11-20 CN claimed
EP-2970307-B1 PYRAZOLO COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2020-03-11 EP claimed
WO-2019190117-A1 2-CYANOPYRIMIDIN-4-YL CARBAMATE OR UREA DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME 한림제약(주) 2019-10-03 WO claimed
US-4520154-A IMPROVED PHYSICAL PROPERTIES MONSANTO EUROPE, S.A. (BE) 1985-05-28 US claimed
EP-0070143-B1 ORGANIC THIOSULPHATES AND THIOSULPHONATES USEFUL AS STABILISING AGENTS FOR RUBBER VULCANISATES MONSANTO EUROPE S.A./N.V. (BE) 1985-02-20 EP claimed
EP-0129527-A2 Vulcanisable rubber composition and compounds useful as stabilising agents for rubber vulcanisates MONSANTO EUROPE S.A./N.V. (BE) 1984-12-27 EP claimed
US-4417012-A DIENE RUBBER MONSANTO EUROPE S.A. (BE) 1983-11-22 US claimed
EP-0070143-A1 Organic thiosulphates and thiosulphonates useful as stabilising agents for rubber vulcanisates MONSANTO EUROPE S.A./N.V. (BE) 1983-01-19 EP claimed
US-4297492-A STABILIZERS FOR PLASTICS CIBA-GEIGY CORPORATION (US) 1981-10-27 US claimed
US-4161534-A ANTHELMINTICS CIBA-GEIGY CORPORATION (US) 1979-07-17 US claimed
US-4064265-A ANTHELMINTICS CIBA-GEIGY CORPORATION (US) 1977-12-20 US claimed
US-4048153-A Azo dyes having an optionally substituted 1-azo-3-nitro-4-arylaminophenyl nucleus SANDOZ LTD. (CH) 1977-09-13 US claimed
US-4018611-A Non-yellowing antimicrobial compositions comprising diiodomethyl sulfones METALORGANA ETABLISSEMENT (FL) 1977-04-19 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210047301-A1 2-CYANOPYRIMIDIN-4-YL CARBAMATE OR UREA DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME CTSK, CTSS, CTSZ HSD17B10 3057/4885ALDH1A1 4627/4885TDP1 3779/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.