Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | MMP2 | P08253 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940308 | 0.88 | MMP1 (0.41) | NPC1RAB9ASMN1; SMN2ADAM17POLB | |
| SCHEMBL6941574 | 0.70 | ADAM17 (0.38) | ADAM17POLBMMP2MMP3 | |
| SCHEMBL7076167 | 0.69 | ADAM17 (0.39) | ADAM17MMP2MMP3LMNA | |
| Hydrochloric Acid SCHEMBL1723578 | 0.69 | TAS1R3 (0.39) | RAB9AKMT2ALMNA | |
| SCHEMBL6939987 | 0.67 | NPC1 (0.33) | NPC1RAB9ASMN1; SMN2ADAM17POLB | |
| SCHEMBL8113733 | 0.65 | CTSD (0.55) | SMN1; SMN2POLBKMT2AKDM4AALDH1A1 | |
| SCHEMBL5156435 | 0.65 | POLB (0.47) | NPC1RAB9ASMN1; SMN2ADAM17POLB | |
| SCHEMBL7313835 | 0.64 | TAS1R3 (0.46) | POLBALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27538012 | 0.63 | TAS1R3 (0.47) | SMN1; SMN2KMT2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL20363288 | 0.63 | POLB (0.50) | SMN1; SMN2POLBMMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |