Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 4/20 | 0.35 |
| ▸ | MMP9 | P14780 | 4/20 | 0.35 |
| ▸ | MMP8 | P22894 | 3/20 | 0.35 |
| ▸ | MMP1 | P03956 | 5/20 | 0.34 |
| ▸ | MMP3 | P08254 | 5/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939987 | 0.92 | NPC1 (0.33) | ADAM17LMNA | |
| SCHEMBL6941761 | 0.88 | TAS1R3 (0.33) | ADAM17MMP2 | |
| SCHEMBL6941574 | 0.84 | ADAM17 (0.38) | ADAM17MMP2MMP9MMP8MMP1 | |
| SCHEMBL6942497 | 0.83 | RAB9A (0.34) | LMNA | |
| SCHEMBL6939946 | 0.82 | NPC1 (0.36) | — | |
| SCHEMBL6945854 | 0.81 | ADAM17 (0.37) | ADAM17 | |
| SCHEMBL6940036 | 0.78 | TSHR (0.38) | TSHR | |
| SCHEMBL6944737 | 0.76 | MMP9 (0.36) | MMP9MMP1MMP13 | |
| SCHEMBL6943877 | 0.74 | — | — | |
| SCHEMBL6942799 | 0.73 | ADAM17 (0.34) | ADAM17LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |