Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944592 | 0.88 | NPC1 (0.38) | MMP3NPC1RAB9ASMN1; SMN2ADAM17 | |
| SCHEMBL6942707 | 0.82 | CTSC (0.35) | SMN1; SMN2KMT2A | |
| SCHEMBL6943384 | 0.79 | MMP1 (0.39) | MMP1MMP3MMP9CTSKADAM17 | |
| SCHEMBL6944740 | 0.74 | CHRNB2 (0.36) | RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7853167 | 0.69 | MMP1 (0.46) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL7836454 | 0.69 | MMP1 (0.46) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL7827850 | 0.69 | MMP1 (0.46) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL7853162 | 0.69 | MMP1 (0.46) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL27378826 | 0.69 | MMP3 (0.47) | MMP1MMP3MMP9 | |
| SCHEMBL6941574 | 0.69 | ADAM17 (0.38) | MMP1MMP3MMP9ADAM17POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |