Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.39 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936917 | 0.85 | RORC (0.54) | RORCOPRM1OPRK1 | |
| SCHEMBL6936920 | 0.85 | RORC (0.54) | RORCOPRM1OPRK1 | |
| SCHEMBL6939720 | 0.83 | MMP8 (0.53) | RORCPLAUBDKRB2BDKRB1BRD4 | |
| SCHEMBL6944021 | 0.83 | MMP8 (0.53) | RORCPLAUBDKRB2BDKRB1BRD4 | |
| SCHEMBL6938724 | 0.80 | CCR1 (0.43) | RORCBDKRB2BDKRB1 | |
| SCHEMBL7649083 | 0.80 | ALDH1A1 (0.54) | RORCPLAUBDKRB2BDKRB1BRD4 | |
| SCHEMBL7718792 | 0.80 | BDKRB2 (0.49) | RORCBDKRB2BDKRB1 | |
| SCHEMBL7811395 | 0.78 | BDKRB2 (0.60) | RORCBDKRB2BDKRB1 | |
| SCHEMBL7643692 | 0.77 | RORC (0.45) | RORCPLAUBDKRB2BDKRB1BRD4 | |
| SCHEMBL6942963 | 0.76 | TSHR (0.54) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155013-B1 | HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS | FOURNIER IND & SANTE (FR) | 2003-07-23 | — | — | EP | disclosed |
| US-6479515-B1 | FOR THE TREATMENT OF PAIN AND INFLAMMATION, AND ESPECIALLY IN THE TREATMENT OF ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS | FOURNIER INDUSTRIE ET SANTE (FR) | 2002-11-12 | — | — | US | disclosed |
| EP-1155013-A1 | HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS | FOURNIER INDUSTRIE ET SANTE (FR) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050418-A9 | HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS | FOURNIER IND & SANTE (FR) | 2001-02-22 | — | — | WO | disclosed |
| WO-2000050418-A1 | HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS | FOURNIER INDUSTRIE ET SANTE (FR) | 2000-08-31 | — | — | WO | disclosed |