Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946473 | 0.88 | NPC1 (0.50) | GAABRD4CREBBPPARP1DHODH | |
| SCHEMBL6951804 | 0.84 | HTR6 (0.52) | GRIN2BGRIN1GAAHTR6BRD4 | |
| SCHEMBL6950138 | 0.79 | KMT2A (0.49) | GRIN2BGRIN1GAAPKMSMN1; SMN2 | |
| SCHEMBL6948942 | 0.77 | BRD4 (0.50) | GAABRD4CREBBPSMN1; SMN2PARP1 | |
| SCHEMBL6949839 | 0.77 | CHEK1 (0.50) | BRD4CREBBPPARP1 | |
| SCHEMBL6948419 | 0.76 | PARP1 (0.45) | GAABRD4CREBBPPARP1RNASEH1 | |
| SCHEMBL9540471 | 0.76 | GRIN2B (0.77) | GRIN2BGRIN1GAAHTR6PKM | |
| SCHEMBL6542830 | 0.74 | GAA (0.60) | GRIN2BGRIN1GAAHTR6PKM | |
| SCHEMBL6948954 | 0.74 | NPC1 (0.55) | PARP1DHODHRNASEH1 | |
| SCHEMBL6946441 | 0.73 | PARP1 (0.48) | GAABRD4CREBBPPARP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |