Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 14/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 14/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953856 | 0.84 | MTNR1A (0.52) | MTNR1AMTNR1B | |
| Cyclopropane SCHEMBL6948950 | 0.84 | MTNR1A (0.39) | MTNR1AMTNR1BABCB11SIGMAR1USP2 | |
| SCHEMBL6950797 | 0.79 | MTNR1A (0.37) | MTNR1AMTNR1BMAPT | |
| SCHEMBL6950864 | 0.79 | MTNR1A (0.56) | MTNR1AMTNR1B | |
| SCHEMBL6956175 | 0.73 | MTNR1B (0.37) | MTNR1AMTNR1BTSHR | |
| SCHEMBL6956181 | 0.73 | HTR2C (0.35) | — | |
| SCHEMBL14115859 | 0.72 | NAMPT (0.40) | MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL6955982 | 0.72 | HTR2C (0.35) | — | |
| SCHEMBL18301929 | 0.70 | AKR1B1 (0.47) | MTNR1AMTNR1BABCB11SIGMAR1TSHR | |
| SCHEMBL6950270 | 0.70 | MTNR1B (0.56) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901483-B1 | BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS | GLAXO GROUP LTD (GB) | 2003-07-09 | — | — | EP | claimed |
| US-5981572-A | Benzofurans and benzopyrans as chronobiological agents | GLAXO WELLCOME INC. (US) | 1999-11-09 | — | — | US | claimed |
| EP-0901483-B1 | BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS | GLAXO GROUP LTD (GB) | 2003-07-09 | — | — | EP | disclosed |
| US-5981572-A | Benzofurans and benzopyrans as chronobiological agents | GLAXO WELLCOME INC. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0901483-A2 | BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS | GLAXO GROUP LIMITED (GB) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043272-A2 | BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS | GLAXO GROUP LIMITED (GB) | 1997-11-20 | — | — | WO | disclosed |