Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 5/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948602 | 0.80 | MEN1 (0.44) | KMT2AMEN1POLBTACR1BRD4 | |
| SCHEMBL9254157 | 0.76 | SIGMAR1 (0.51) | KMT2AMEN1KDM1AMAOAMAOB | |
| SCHEMBL11215454 | 0.75 | SMN1; SMN2 (0.40) | KMT2AMEN1ATMKDM1AHSD17B10 | |
| SCHEMBL3256065 | 0.72 | MEN1 (0.57) | KMT2AMEN1ATMPOLBKDM1A | |
| SCHEMBL11221891 | 0.72 | SLC18A3 (0.41) | KMT2AMEN1ATMKDM4E | |
| SCHEMBL6960206 | 0.68 | GNAI3 (0.53) | KMT2AMEN1POLBTACR1USP2 | |
| SCHEMBL7209206 | 0.67 | ACHE (0.60) | KMT2AMEN1USP2HSD17B10 | |
| SCHEMBL2919640 | 0.65 | MEN1 (0.56) | KMT2AMEN1TACR1USP2KDM4E | |
| SCHEMBL2919331 | 0.65 | GNAI3 (0.54) | KMT2AMEN1POLBTACR1USP2 | |
| SCHEMBL7484195 | 0.65 | ACHE (0.68) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699665-B1 | Imidazoline derivatives, their preparation and their use as tachykinin receptor antagonists | LILLY CO ELI (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6175013-B1 | 1-(2-METHOXYBENZYL)-2-((4-PHENYL-1-PIPERAZINYL)METHYL)-4-(1H -INDOL-3-YLMETHYL)-2-IMIDAZOLINE, FOR EXAMPLE; ADMINSTERING TO TREAT ANXIETY, DEPRESSION, PSYCHOSIS, AND SCHIZOPHRENIA | ELI LILLY AND COMPANY | 2001-01-16 | — | — | US | disclosed |
| EP-0699665-A1 | Imidazoline derivatives, their preparation and their use as tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-03-06 | — | — | EP | disclosed |