Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950162 | 0.80 | KMT2A (0.47) | MEN1KMT2APOLBTACR1KDM4E | |
| Ammonia Solution, Strong SCHEMBL28870087 | 0.66 | PDE5A (0.39) | — | |
| SCHEMBL9446993 | 0.65 | BRD4 (0.42) | POLBBRD4LMNAMAPTSIGMAR1 | |
| SCHEMBL2919640 | 0.64 | MEN1 (0.56) | MEN1KMT2ATACR1CXCR4KDM4E | |
| SCHEMBL2919331 | 0.64 | GNAI3 (0.54) | MEN1KMT2APOLBTACR1CXCR4 | |
| SCHEMBL621779 | 0.63 | HTR1A (0.58) | LMNA | |
| SCHEMBL7209206 | 0.62 | ACHE (0.60) | MEN1KMT2AKCNH2USP2HSD17B10 | |
| SCHEMBL5536939 | 0.62 | MEN1 (0.48) | MEN1KMT2AKDM4EKCNH2USP2 | |
| SCHEMBL2922060 | 0.62 | GNAI3 (0.49) | MEN1KMT2ATACR1CXCR4KDM4E | |
| SCHEMBL11379176 | 0.62 | SIGMAR1 (0.51) | KCNH2USP2HSD17B10SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699665-B1 | Imidazoline derivatives, their preparation and their use as tachykinin receptor antagonists | LILLY CO ELI (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6175013-B1 | 1-(2-METHOXYBENZYL)-2-((4-PHENYL-1-PIPERAZINYL)METHYL)-4-(1H -INDOL-3-YLMETHYL)-2-IMIDAZOLINE, FOR EXAMPLE; ADMINSTERING TO TREAT ANXIETY, DEPRESSION, PSYCHOSIS, AND SCHIZOPHRENIA | ELI LILLY AND COMPANY | 2001-01-16 | — | — | US | disclosed |
| EP-0699665-A1 | Imidazoline derivatives, their preparation and their use as tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-03-06 | — | — | EP | disclosed |