Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 6/20 | 0.47 |
| ▸ | FEN1 | P39748 | 6/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.43 |
| ▸ | HAO1 | Q9UJM8 | 4/20 | 0.41 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949374 | 0.84 | PTPN1 (0.45) | ERCC5FEN1PTPN1HAO1PLOD2 | |
| SCHEMBL7077395 | 0.82 | WNT3A (0.43) | PIM2PLOD2PIM1WNT3ASMN1; SMN2 | |
| SCHEMBL7073904 | 0.81 | TBXAS1 (0.52) | ERCC5FEN1PTPN1PLOD2 | |
| SCHEMBL7667672 | 0.80 | PIM2 (0.41) | ERCC5FEN1PTPN1PIM2HAO1 | |
| SCHEMBL6947604 | 0.78 | ERCC5 (0.61) | ERCC5FEN1PTPN1HAO1 | |
| SCHEMBL7667601 | 0.75 | PIM2 (0.56) | PIM2PIM1 | |
| SCHEMBL6949384 | 0.75 | ERCC5 (0.46) | ERCC5FEN1PTPN1HAO1SMN1; SMN2 | |
| SCHEMBL6945686 | 0.75 | ERCC5 (0.46) | ERCC5FEN1PTPN1HAO1 | |
| SCHEMBL6948009 | 0.74 | PTPN1 (0.57) | ERCC5FEN1PTPN1HAO1PLOD2 | |
| SCHEMBL6940911 | 0.74 | PTPN1 (0.72) | ERCC5FEN1PTPN1HAO1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |