Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 11/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078799 | 0.86 | PIM2 (0.51) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL7667672 | 0.79 | PIM2 (0.41) | PIM2PIM1 | |
| SCHEMBL6946070 | 0.78 | PLOD2 (0.46) | HRH1HRH4HRH2HRH3 | |
| SCHEMBL7079196 | 0.76 | PIM2 (0.45) | PIM2DYRK1AKLKB1KLK1 | |
| SCHEMBL6950602 | 0.75 | ERCC5 (0.47) | PIM2PIM1 | |
| SCHEMBL2213805 | 0.72 | PIM2 (1.00) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL6945686 | 0.71 | ERCC5 (0.46) | — | |
| SCHEMBL6947604 | 0.70 | ERCC5 (0.61) | — | |
| SCHEMBL2211724 | 0.69 | PIM2 (1.00) | PIM2PIM1CSNK2A2CSNK2A1 | |
| SCHEMBL3364837 | 0.69 | PIM2 (0.72) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |