Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14710459 | 0.72 | HTT (0.75) | SMN1; SMN2HTTMAPK10MAPK1HSD17B10 | |
| SCHEMBL19209480 | 0.70 | PDE4D (0.59) | SMN1; SMN2HTTMAPK10NPSR1HSD17B10 | |
| SCHEMBL13495378 | 0.68 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTMAPK10NPSR1HSD17B10 | |
| SCHEMBL6161826 | 0.68 | KMT2A (0.43) | SMN1; SMN2HTTMAPK1HSD17B10KDM4E | |
| SCHEMBL16268584 | 0.68 | HTT (0.65) | SMN1; SMN2HTTMAPK10HSD17B10KDM4E | |
| SCHEMBL9714922 | 0.68 | ALDH1A1 (0.44) | SMN1; SMN2HTTMAPK10NPSR1MAPK1 | |
| SCHEMBL958967 | 0.67 | KDM4E (0.72) | SMN1; SMN2HTTMAPK10MAPK1HSD17B10 | |
| SCHEMBL9714918 | 0.67 | LMNA (0.54) | SMN1; SMN2HTTMAPK10NPSR1MAPK1 | |
| SCHEMBL24442343 | 0.66 | PIK3CD (0.52) | SMN1; SMN2HTTMAPK10RPS6KA3 | |
| SCHEMBL9714945 | 0.66 | HSD17B10 (0.46) | SMN1; SMN2HTTMAPK10NPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368345-A1 | ALKOXYCARBONYLAMINO HETEROARYL CARBOXYLIC ACID DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002070514-A1 | ALKOXYCARBONYLAMINO HETEROARYL CARBOXYLIC ACID DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-12 | — | — | WO | disclosed |