Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950361 | 0.81 | CYP19A1 (0.46) | ADRA2AOPRM1OPRL1 | |
| SCHEMBL6955604 | 0.73 | ADRA2A (0.49) | ADRA2AADRA2BADRA2C | |
| SCHEMBL6951819 | 0.73 | ADRA2A (0.36) | ADRA2A | |
| Fumaric Acid SCHEMBL8097411 | 0.72 | CYP19A1 (0.38) | ADRA2A | |
| Fumaric Acid SCHEMBL8097408 | 0.72 | CYP19A1 (0.38) | ADRA2A | |
| SCHEMBL24210488 | 0.72 | CYP2D6 (0.45) | PNMTADRA2ACYP2D6ADRA2BADRA2C | |
| SCHEMBL6950989 | 0.71 | SLC6A4 (0.45) | ADRA2AHTR2CADRA2BADRA2C | |
| SCHEMBL8100204 | 0.67 | OPRM1 (0.31) | OPRM1OPRD1OPRK1OPRL1TRPV1 | |
| SCHEMBL6959118 | 0.67 | SLC6A4 (0.38) | PNMTADRA2AHTR2CADRA2BADRA2C | |
| SCHEMBL6950977 | 0.66 | ADRA2A (0.59) | PNMTADRA2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |