Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988541 | 0.80 | SIGMAR1 (0.35) | SLC6A2SLC6A4SLC6A3HRH3 | |
| SCHEMBL4382303 | 0.77 | HPGD (0.38) | SLC6A2SLC6A4SLC6A3HRH3 | |
| SCHEMBL1854582 | 0.72 | GPR119 (0.57) | LMNAGPR119NAMPT | |
| SCHEMBL6989033 | 0.69 | CACNA2D1 (0.45) | GPR119 | |
| SCHEMBL6950631 | 0.69 | GPR119 (0.53) | LMNAGPR119NAMPT | |
| SCHEMBL27745535 | 0.68 | LMNA (0.48) | LMNATP53ROCK2PRKG1PRCP | |
| Tert-Butyl Formate SCHEMBL27745536 | 0.68 | HTR2C (0.44) | TP53SLC6A2SLC6A4SLC6A3P2RY14 | |
| SCHEMBL6590305 | 0.68 | KCNA3 (0.46) | NAMPT | |
| SCHEMBL31566742 | 0.68 | PDE4B (0.58) | LMNATP53GPR119NAMPT | |
| SCHEMBL29880481 | 0.68 | PDE4B (0.58) | LMNATP53GPR119NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966462-B1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-06-11 | — | — | EP | disclosed |
| US-6391880-B1 | ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 2002-05-21 | — | — | US | disclosed |
| EP-0966462-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998035959-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |