Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.53 |
| ▸ | DRD2 | P14416 | 6/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 7/20 | 0.48 |
| ▸ | HTR7 | P34969 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6960476 | 0.99 | DRD3 (0.52) | DRD3DRD2DRD4HTR1AHTR7 | |
| SCHEMBL6952207 | 0.97 | HTR1A (0.49) | DRD3DRD2DRD4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL6959796 | 0.96 | HTR1A (0.48) | DRD3DRD2DRD4HTR1AHTR7 | |
| SCHEMBL7081609 | 0.93 | DRD2 (0.46) | DRD3DRD2DRD4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL6957118 | 0.92 | DRD2 (0.45) | DRD3DRD2DRD4HTR1AHTR7 | |
| SCHEMBL6953511 | 0.86 | ADORA1 (0.47) | DRD3DRD2DRD4HTR7ADORA1 | |
| Hydrochloric Acid SCHEMBL6959246 | 0.85 | ADORA1 (0.46) | DRD3DRD2DRD4HTR7ADORA1 | |
| SCHEMBL7082241 | 0.83 | SIGMAR1 (0.52) | DRD3DRD2DRD4HTR1ADRD1 | |
| Hydrochloric Acid SCHEMBL6956636 | 0.82 | DRD2 (0.52) | DRD3DRD2DRD4HTR1ADRD1 | |
| SCHEMBL7084707 | 0.80 | SIGMAR1 (0.57) | DRD3DRD2DRD4HTR1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851862-B1 | 1(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF 5-HT1A-RECEPTOR MEDIATED DISORDERS | PHARMACIA ITALIA SPA (IT) | 2003-09-10 | — | — | EP | claimed |
| EP-0851862-B1 | 1(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF 5-HT1A-RECEPTOR MEDIATED DISORDERS | PHARMACIA ITALIA SPA (IT) | 2003-09-10 | — | — | EP | disclosed |
| EP-0851862-A1 | 1(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF 5-HT1A-RECEPTOR MEDIATED DISORDERS | Pharmacia Italia S.p.A. (IT) | 1998-07-08 | — | — | EP | disclosed |
| WO-1997008159-A1 | 1(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF 5-HT1A-RECEPTOR MEDIATED DISORDERS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-03-06 | — | — | WO | disclosed |