Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463941 | 0.83 | LMNA (0.41) | TSHRALDH1A1LMNAPOLBHSP90AA1 | |
| SCHEMBL3103834 | 0.80 | STAT3 (0.48) | STAT3ALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL30844048 | 0.78 | MAPT (0.44) | STAT3TSHRALDH1A1 | |
| SCHEMBL6965004 | 0.78 | MMP1 (0.47) | TSHRALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL26079065 | 0.78 | RORC (0.42) | STAT3TSHRALDH1A1KMT2ALMNA | |
| SCHEMBL6489184 | 0.78 | KDM4E (0.40) | STAT3TSHRALDH1A1SMN1; SMN2GPR139 | |
| SCHEMBL29030128 | 0.77 | KMT2A (0.42) | TSHRALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL17023780 | 0.77 | CYP3A4 (0.40) | STAT3ALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL791306 | 0.76 | CA2 (0.56) | STAT3TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL11395491 | 0.76 | ALDH1A1 (0.34) | STAT3TSHRALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562808-B1 | Calcium channel antagonists effective in treating intestinal diseases caused by abnormal acceleration of the contraction of intestinal tracts such as irritable bowel syndrome, without significant cardiac effects | AJINOMOTO CO., INC. (JP) | 2003-05-13 | — | — | US | disclosed |
| EP-1020466-B1 | 5,11-DIHYDRODIBENZ[b,e][1,4]OXAZEPINE DERIVATIVES AND MEDICINAL COMPOSITION CONTAINING THE SAME | AJINOMOTO KK (JP) | 2003-02-19 | — | — | EP | disclosed |
| CN-1278816-A | 5, 11-dihydrodibenzo [ b, e ] [1,4] oxazepine * derivatives and pharmaceutical compositions containing the same | AJINOMOTO KK (JP) | 2001-01-03 | — | — | CN | disclosed |
| EP-1020466-A1 | 5,11-DIHYDRODIBENZ[b,e][1,4]OXAZEPINE DERIVATIVES AND MEDICINAL COMPOSITION CONTAINING THE SAME | Ajinomoto Co., Inc. (JP) | 2000-07-19 | — | — | EP | disclosed |