Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14867646 | 0.81 | KMT2A (0.51) | MAPTPOLBIMPDH2SIRT2ALDH1A1 | |
| SCHEMBL13701820 | 0.77 | MTOR (0.50) | MAPTPOLBIMPDH2SIRT2MAPK14 | |
| SCHEMBL13240435 | 0.77 | CHRNA1 (0.59) | MAPTPOLBKMT2AGAAMEN1 | |
| SCHEMBL12037438 | 0.75 | CYP2A6 (0.44) | MAPTLMNAALDH1A1KMT2ARAB9A | |
| SCHEMBL10079468 | 0.75 | MAPT (0.51) | MAPTPOLBLMNAALDH1A1KMT2A | |
| SCHEMBL85865 | 0.75 | CA1 (0.50) | MAPTLMNAALDH1A1KMT2AGAA | |
| SCHEMBL16976360 | 0.74 | GABRA1 (0.43) | MAPTLMNAALDH1A1KMT2ACYP2C19 | |
| SCHEMBL6997419 | 0.74 | TAS1R3 (0.52) | MAPTPOLBIMPDH2ALDH1A1KMT2A | |
| SCHEMBL17865779 | 0.74 | LMNA (0.58) | MAPTPOLBSIRT2LMNAHTT | |
| SCHEMBL14707993 | 0.74 | HDAC1 (0.43) | MAPTPOLBLMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183293-B2 | Phenyl acetic acid derivatives | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090275659-A1 | Phenyl acetic acid derivatives as inflammation modulators | AMGEN INC. (US) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275659-A1 | Phenyl acetic acid derivatives as inflammation modulators | NFKBIA, HCAR2, NFATC1 | MAPT 538/4885POLB 3980/4885IMPDH2 3222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.