Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.43 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.42 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6957258 | 1.00 | HCAR2 (0.48) | HCAR2SIGMAR1EGFRHRH1KDM4E | |
| SCHEMBL5788869 | 0.88 | SIGMAR1 (0.59) | SIGMAR1EGFRHTR1ASLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL5945716 | 0.81 | SIGMAR1 (0.74) | SIGMAR1KMT2A | |
| Fumaric Acid SCHEMBL1395281 | 0.81 | SIGMAR1 (0.74) | SIGMAR1KMT2A | |
| Fumaric Acid SCHEMBL7488785 | 0.81 | SIGMAR1 (0.74) | SIGMAR1KMT2A | |
| Fumaric Acid SCHEMBL7488780 | 0.81 | SIGMAR1 (0.74) | SIGMAR1KMT2A | |
| Fumaric Acid SCHEMBL1319836 | 0.77 | HCAR2 (0.69) | HCAR2KDM4ESLC6A2SLC6A3KMT2A | |
| Maleic Acid SCHEMBL1319832 | 0.77 | HCAR2 (0.69) | HCAR2KDM4ESLC6A2SLC6A3KMT2A | |
| SCHEMBL28236368 | 0.75 | ALDH1A1 (0.51) | SIGMAR1EGFRKMT2A | |
| SCHEMBL5188945 | 0.75 | TEAD3 (0.52) | KDM4ETEAD3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |
| CN-1365359-A | Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists | LILLY CO ELI (US) | 2002-08-21 | — | — | CN | disclosed |
| EP-1204654-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009111-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |