Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD3 | Q99594 | 2/20 | 0.52 |
| ▸ | GRM5 | P41594 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5002349 | 0.82 | CHRM2 (0.53) | TEAD3KMT2AMEN1KDM4E | |
| SCHEMBL13992754 | 0.80 | TSHR (0.47) | TEAD3GRM5KMT2AALDH1A1LMNA | |
| SCHEMBL30128338 | 0.79 | LTA4H (0.56) | TEAD3LMNATSHR | |
| SCHEMBL4663018 | 0.79 | LTA4H (0.60) | LMNASMN1; SMN2KDM4ETSHR | |
| SCHEMBL7301909 | 0.78 | LMNA (0.59) | LMNASMN1; SMN2TSHR | |
| SCHEMBL2850013 | 0.78 | ALDH1A1 (0.70) | KMT2AALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL6237770 | 0.77 | GRM5 (0.48) | TEAD3GRM5ALDH1A1LMNAGAA | |
| SCHEMBL3795583 | 0.77 | MEN1 (0.69) | KMT2AALDH1A1SMN1; SMN2MEN1GAA | |
| SCHEMBL5235142 | 0.75 | CTSL (0.55) | ALDH1A1SMN1; SMN2 | |
| Fumaric Acid SCHEMBL6957258 | 0.75 | HCAR2 (0.48) | TEAD3KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812453-A1 | METHOD OF PREPARING OR SYNTHESIZING POLYAZAMACROCYCLE DERIVATIVES | Therapharm GmbH (CH) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006045546-A1 | METHOD OF PREPARING OR SYNTHESIZING POLYAZAMACROCYCLE DERIVATIVES | THERAPHARM GMBH (CH) | 2006-05-04 | — | — | WO | disclosed |