Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962300 | 0.80 | MEN1 (0.34) | SMYD3ALDH1A1NPC1POLB | |
| SCHEMBL6967183 | 0.80 | JAK2 (0.32) | SMYD3ALDH1A1 | |
| SCHEMBL6958233 | 0.80 | JAK2 (0.32) | SMYD3ALDH1A1 | |
| SCHEMBL7234984 | 0.77 | L3MBTL1 (0.31) | SMYD3 | |
| SCHEMBL6969165 | 0.75 | JAK2 (0.30) | — | |
| SCHEMBL6959434 | 0.74 | SPHK1 (0.36) | — | |
| SCHEMBL6959128 | 0.74 | SPHK1 (0.36) | — | |
| SCHEMBL6968537 | 0.73 | ALOX5 (0.35) | ALDH1A1 | |
| SCHEMBL6970227 | 0.71 | CCR4 (0.42) | SMYD3 | |
| SCHEMBL6963805 | 0.69 | ALDH1A1 (0.46) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |
| US-6610707-B1 | Moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage. | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |