Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963805 | 0.85 | ALDH1A1 (0.46) | FKBP1AALDH1A1MMP8MMP12MMP13 | |
| SCHEMBL6959434 | 0.83 | SPHK1 (0.36) | FKBP1ACHRM5ADRA2CSPHK1 | |
| SCHEMBL6959128 | 0.83 | SPHK1 (0.36) | FKBP1ACHRM5ADRA2CSPHK1 | |
| SCHEMBL6958233 | 0.80 | JAK2 (0.32) | FKBP1AALDH1A1MMP1MMP7MMP13 | |
| SCHEMBL6967183 | 0.80 | JAK2 (0.32) | FKBP1AALDH1A1MMP1MMP7MMP13 | |
| SCHEMBL8132660 | 0.77 | MMP13 (0.35) | FKBP1ACHRM5ADRA2CMMP1MMP7 | |
| SCHEMBL6969165 | 0.77 | JAK2 (0.30) | — | |
| SCHEMBL8427907 | 0.76 | SMN1; SMN2 (0.39) | FKBP1AALDH1A1SMN1; SMN2MMP1MMP7 | |
| SCHEMBL19902090 | 0.76 | SMN1; SMN2 (0.39) | FKBP1AALDH1A1SMN1; SMN2MMP1MMP7 | |
| SCHEMBL3941213 | 0.74 | LMNA (0.48) | ALDH1A1SMN1; SMN2NPSR1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |
| US-6610707-B1 | Moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage. | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1060178-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999045006-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 1999-09-10 | — | — | WO | disclosed |