Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959434 | 1.00 | SPHK1 (0.36) | SPHK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL6968537 | 0.83 | ALOX5 (0.35) | SPHK1FKBP1ACHRM5ADRA2C | |
| SCHEMBL6958233 | 0.81 | JAK2 (0.32) | JAK2JAK1TYK2JAK3FKBP1A | |
| SCHEMBL6967183 | 0.81 | JAK2 (0.32) | JAK2JAK1TYK2JAK3FKBP1A | |
| SCHEMBL6969165 | 0.81 | JAK2 (0.30) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL6963805 | 0.78 | ALDH1A1 (0.46) | FKBP1A | |
| SCHEMBL6962300 | 0.75 | MEN1 (0.34) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL6964491 | 0.74 | KDM4E (0.35) | — | |
| SCHEMBL8132660 | 0.73 | MMP13 (0.35) | FKBP1ACHRM5ADRA2C | |
| SCHEMBL7234984 | 0.72 | L3MBTL1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |
| US-6610707-B1 | Moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage. | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1060178-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999045006-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 1999-09-10 | — | — | WO | disclosed |