SCHEMBL6958864

SCHEMBL6958864

OC1CCc2ccc(Cl)cc2C1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.46
HTR2C P28335 1/20 0.46
HTR2B P41595 1/20 0.46
DRD2 P14416 8/20 0.45
DRD3 P35462 8/20 0.45
DRD4 P21917 5/20 0.45
PNMT P11086 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP11B1 P15538 1/20 0.42
CYP11B2 P19099 1/20 0.42
SRD5A1 P18405 2/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
HTR1A P08908 1/20 0.40
ADRB2 P07550 1/20 0.40
CYP2D6 P10635 1/20 0.40
CASP1 P29466 1/20 0.40
GRIN2B Q13224 1/20 0.39
LMNA P02545 2/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6951077 0.92 CYP1A2 (0.49) HTR2AHTR2CHTR2BDRD2DRD3
SCHEMBL24387477 0.84 PNMT (0.44) HTR2AHTR2CHTR2BPNMTHTT
SCHEMBL2564622 0.82 DRD3 (0.65) DRD2DRD3DRD4CYP1A2MEN1
SCHEMBL30199160 0.82 DRD3 (0.65) DRD2DRD3DRD4CYP1A2MEN1
SCHEMBL6957971 0.78 SIGMAR1 (0.42) DRD2DRD3DRD4CYP1A2CYP11B1
SCHEMBL13799412 0.77 HTR2A (0.46) HTR2AHTR2CHTR2BDRD2DRD3
SCHEMBL14037504 0.77 DRD2 (0.44) DRD2DRD3DRD4CYP1A2CYP11B1
SCHEMBL5017850 0.77 DRD2 (0.44) DRD2DRD3DRD4CYP1A2CYP11B1
SCHEMBL14037505 0.77 DRD2 (0.44) DRD2DRD3DRD4CYP1A2CYP11B1
SCHEMBL6950358 0.77 HTR1D (0.43) HTR2AHTR2CHTR2BDRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0757677-B1 BENZOCYCLOHEXYLIMIDAZOLETHIONE DERIVATIVES SYNTEX LLC (US) 2003-06-18 EP disclosed
US-5719280-A REACTING AMINE SUBSTITUTED BENZOCYCLOALKANE WITH DIALKYLOXYACETALDEHYDE IN PRESENCE OF REDUCING AGENT OR CATALYTIC HYDROGENATION, TREATING WITH THIOCYANIC ACID SYNTEX (U.S.A.) INC. (US) 1998-02-17 US disclosed
EP-0757677-A1 BENZOCYCLOALKYLAZOLETHIONE DERIVATIVES SYNTEX (U.S.A.) INC. (US) 1997-02-12 EP disclosed
US-5538988-A CARDIOVASCULAR DISORDERS AND DOPAMINE HYDROLASE ENZYME INHIBITORS SYNTEX (U.S.A.) INC. 1996-07-23 US disclosed
WO-1995029165-A2 BENZOCYCLOALKYLAZ0LETHIONE DERIVATIVES AS DOPAMIN BETA-HYDROXYLASE INHIBITORS SYNTEX (U.S.A.) INC. (US) 1995-11-02 WO disclosed