Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960697 | 0.85 | MEN1 (0.33) | SLC6A4SLC6A3TRPV1 | |
| SCHEMBL6041482 | 0.83 | MDM2 (0.36) | MDM2TRPV1 | |
| SCHEMBL6953266 | 0.78 | SLC6A3 (0.41) | MDM2SLC6A3 | |
| SCHEMBL6042862 | 0.77 | ALDH1A1 (0.36) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL6954522 | 0.74 | ESR2 (0.35) | — | |
| SCHEMBL7074672 | 0.73 | MDM2 (0.33) | MDM2 | |
| SCHEMBL6041346 | 0.70 | CCR1 (0.37) | MDM2 | |
| SCHEMBL6041780 | 0.67 | GBA1 (0.39) | SLC6A4SLC6A3SLC6A2TRPV1 | |
| SCHEMBL6205181 | 0.65 | HSD11B1 (0.48) | — | |
| SCHEMBL6951399 | 0.65 | SLC6A3 (0.37) | MDM2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |