Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093012 | 0.75 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2CYP19A1ACHE | |
| SCHEMBL5608451 | 0.70 | CYP19A1 (0.59) | SMN1; SMN2CYP19A1ACHEALDH1A1MAPT | |
| SCHEMBL947365 | 0.69 | ALDH1A1 (0.55) | NPC1RAB9ASMN1; SMN2ACHEPTGS2 | |
| SCHEMBL29625779 | 0.69 | ALDH1A1 (0.50) | NPC1RAB9ASMN1; SMN2CYP19A1ACHE | |
| SCHEMBL29683518 | 0.69 | ALDH1A1 (0.55) | NPC1RAB9ASMN1; SMN2ACHEPTGS2 | |
| SCHEMBL7518685 | 0.68 | CYP19A1 (0.49) | NPC1RAB9ASMN1; SMN2CYP19A1ACHE | |
| SCHEMBL7714698 | 0.68 | HTR7 (0.52) | CYP19A1ACHESIGMAR1HTR2CDRD2 | |
| SCHEMBL25001243 | 0.68 | ACHE (0.66) | NPC1RAB9ASMN1; SMN2CYP19A1ACHE | |
| SCHEMBL10000875 | 0.68 | ACHE (0.66) | NPC1RAB9ASMN1; SMN2CYP19A1ACHE | |
| SCHEMBL12676173 | 0.68 | ACHE (0.66) | NPC1RAB9ASMN1; SMN2CYP19A1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |