Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17444512 | 0.71 | AKT2 (0.43) | AKT1AKT2MAPK1AURKAAURKB | |
| SCHEMBL1967310 | 0.71 | IDO1 (0.38) | ALDH1A1RAB9ANPC1MAPK1NOTUM | |
| SCHEMBL978671 | 0.69 | ALDH1A1 (0.44) | ALDH1A1ALOX15RAB9AMAPK1MEN1 | |
| SCHEMBL978864 | 0.67 | ALDH1A1 (0.42) | ALDH1A1ALOX15RAB9ANPC1MEN1 | |
| Biphenyl SCHEMBL4707139 | 0.61 | ALDH1A1 (0.90) | AKT1AKT2ALDH1A1RAB9ANPC1 | |
| Biphenyl SCHEMBL11347002 | 0.61 | ALDH1A1 (0.90) | ALDH1A1RAB9ANPC1MAPK1NOTUM | |
| SCHEMBL5047733 | 0.59 | ALDH1A1 (0.47) | ALDH1A1ALOX15RAB9ANPC1MAPK1 | |
| Biphenyl SCHEMBL1358618 | 0.57 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1MAPK1NOTUM | |
| Biphenyl SCHEMBL4002609 | 0.57 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1MAPK1NOTUM | |
| Biphenyl SCHEMBL164 | 0.57 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1MAPK1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 445 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023244815-A1 | MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | claimed |
| US-20230374014-A1 | CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-11-23 | — | — | US | claimed |
| EP-3891145-B1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS INC (US) | 2023-04-12 | — | — | EP | claimed |
| EP-4153593-A1 | CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-03-29 | — | — | EP | claimed |
| CN-115667265-A | CGAS-inhibiting triazolopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | claimed |
| US-20220017502-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2022-01-20 | — | — | US | claimed |
| WO-2021233852-A1 | CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-11-25 | — | — | WO | claimed |
| EP-3891145-A1 | MODULATORS OF TREX1 | Constellation Pharmaceuticals, Inc. (US) | 2021-10-13 | — | — | EP | claimed |
| CN-113396149-A | Modulators of TREX1 | 星座制药公司 | 2021-09-14 | — | — | CN | claimed |
| US-11077113-B2 | 6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes | SPRINT BIOSCIENCE AB (SE) | 2021-08-03 | — | — | US | claimed |
| WO-2001096339-A1 | NOVEL TELOMERASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-20 | — | — | WO | claimed |
| EP-1042291-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | Klinge Pharma GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| WO-1999031064-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | claimed |
| EP-0892788-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1999-01-27 | — | — | EP | claimed |
| EP-0874829-A1 | AMINO ACID DERIVATIVES, THE PREPARATION AND USE THEREOF AS ENDOTHELIN ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-11-04 | — | — | EP | claimed |
| WO-1997038982-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-23 | — | — | WO | claimed |
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | claimed |
| WO-1997012878-A1 | AMINO ACID DERIVATIVES, THE PREPARATION AND USE THEREOF AS ENDOTHELIN ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1997-04-10 | — | — | WO | claimed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | claimed |
| US-4310619-A | LIGHT SENSITIVE ELEMENT COMPRISING A 5-PYRAZOLONE COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1982-01-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11077113-B2 | 6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes | PYCR1, GPR119, IL6 | AKT1 3568/4885AKT2 3690/4885ALDH1A1 1644/4885 |
| US-20230374014-A1 | CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES | CGAS, GLS2, GBA3 | AKT1 2624/4885AKT2 3271/4885ALDH1A1 928/4885 |
| US-20220017502-A1 | MODULATORS OF TREX1 | CFTR, SLC10A1, CYP27A1 | AKT1 4181/4885AKT2 3914/4885ALDH1A1 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.