Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.42 |
| ▸ | BCL9 | O00512 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27930565 | 0.81 | RAB9A (0.54) | ALDH1A1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL527544 | 0.72 | KMT2A (0.71) | ALDH1A1GAAKDM4EKMT2APKM | |
| SCHEMBL11021047 | 0.71 | MAPT (0.62) | ALDH1A1GAAKDM4EKMT2APKM | |
| SCHEMBL30439305 | 0.70 | BCL9 (0.44) | ALDH1A1GAAKDM4EKMT2APKM | |
| SCHEMBL542043 | 0.70 | KMT2A (0.84) | ALDH1A1GAAKMT2APKMMAPT | |
| SCHEMBL4951809 | 0.70 | KMT2A (0.84) | ALDH1A1GAAKMT2APKMMAPT | |
| SCHEMBL18434657 | 0.70 | KMT2A (0.84) | ALDH1A1GAAKMT2APKMMAPT | |
| SCHEMBL10636579 | 0.70 | KMT2A (0.84) | ALDH1A1GAAKMT2APKMMAPT | |
| SCHEMBL4452103 | 0.70 | ALDH1A1 (0.53) | ALDH1A1GAAKDM4EKMT2APKM | |
| SCHEMBL31597009 | 0.70 | MGLL (0.60) | KMT2ARAB9AHPGDMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |