Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14439829 | 0.88 | VCP (0.36) | VCPTDP1DHODHSLC5A2ADAMTS5 | |
| SCHEMBL14439828 | 0.88 | TDP1 (0.40) | VCPTDP1DHODHSLC5A2MDM2 | |
| SCHEMBL6966496 | 0.87 | VCP (0.37) | VCPTDP1DHODHSLC5A2ADAMTS5 | |
| SCHEMBL6973959 | 0.87 | VCP (0.35) | VCPTDP1DHODHSLC5A2ADAMTS5 | |
| SCHEMBL8109133 | 0.87 | VCP (0.35) | VCPTDP1DHODHSLC5A2ADAMTS5 | |
| SCHEMBL14439841 | 0.86 | VCP (0.36) | VCPTDP1DHODHSLC5A2ADAMTS5 | |
| SCHEMBL6965896 | 0.86 | VCP (0.36) | VCPTDP1DHODHSLC5A2ADAMTS5 | |
| SCHEMBL6968770 | 0.85 | TDP1 (0.35) | VCPTDP1SLC5A2ADAMTS5MMP2 | |
| SCHEMBL14439831 | 0.85 | HDAC1 (0.40) | VCPTDP1DHODHSLC5A2ADAMTS5 | |
| SCHEMBL14439830 | 0.85 | TP53 (0.39) | VCPTDP1DHODHTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |