Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 2/20 | 0.30 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | PLA2G4C | Q9UP65 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968358 | 0.99 | TSHR (0.33) | TSHRTP53CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL6971043 | 0.96 | TSHR (0.30) | TSHR | |
| SCHEMBL6965952 | 0.90 | — | — | |
| SCHEMBL3577333 | 0.80 | TSHR (0.46) | TSHRTP53CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL6967567 | 0.76 | PTPN1 (0.31) | — | |
| SCHEMBL5187673 | 0.72 | TSHR (0.40) | TSHRCYP3A4ALDH1A1LMNAMAPT | |
| SCHEMBL6966305 | 0.69 | — | — | |
| SCHEMBL5002852 | 0.67 | LMNA (0.50) | TSHRTP53CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL6970357 | 0.66 | — | — | |
| SCHEMBL6963313 | 0.66 | FAAH (0.32) | FAAHMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |