Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5539466 | 0.80 | ALDH1A1 (0.58) | ALDH1A1TSHRMAPK1CYP3A4TDP1 | |
| SCHEMBL4405018 | 0.78 | ALDH1A1 (0.70) | ALDH1A1TSHRMAPK1CYP3A4TDP1 | |
| SCHEMBL12679051 | 0.78 | ALDH1A1 (1.00) | ALDH1A1TSHRMAPK1CYP3A4TDP1 | |
| SCHEMBL76217 | 0.78 | ALDH1A1 (1.00) | ALDH1A1TSHRMAPK1CYP3A4TDP1 | |
| SCHEMBL7494593 | 0.77 | ALDH1A1 (0.54) | ALDH1A1TSHRMAPK1CYP3A4TDP1 | |
| SCHEMBL1803971 | 0.76 | ESR1 (0.32) | ALDH1A1TSHRCYP3A4TDP1 | |
| SCHEMBL65261 | 0.76 | ALDH1A1 (1.00) | ALDH1A1TSHRMAPK1CYP3A4TDP1 | |
| SCHEMBL44501 | 0.76 | ALDH1A1 (0.67) | ALDH1A1TSHRMAPK1CYP3A4TDP1 | |
| Hydrochloric Acid SCHEMBL1450346 | 0.76 | ALDH1A1 (0.94) | ALDH1A1TSHRMAPK1CYP3A4TDP1 | |
| SCHEMBL7589217 | 0.75 | ALDH1A1 (0.54) | ALDH1A1TSHRMAPK1CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 201 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450303-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-28 | — | — | US | claimed |
| CN-102459240-A | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV | 2012-05-16 | — | — | CN | claimed |
| EP-2421856-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| US-20100331299-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-30 | — | — | US | claimed |
| WO-2010124112-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |
| US-20100048893-A1 | Substituted arylalkanoic acid derivatives and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2010-02-25 | — | — | US | claimed |
| EP-2006271-A9 | SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2009-07-29 | — | — | EP | claimed |
| US-20090062530-A1 | Substituted arylalkanoic acid derivatives and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-03-05 | — | — | US | claimed |
| US-20090054401-A1 | Substituted bicyclic derivatives and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-02-26 | — | — | US | claimed |
| EP-2006271-A2 | SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2008-12-24 | — | — | EP | claimed |
| US-6464902-B1 | CONDENSATION OF AT LEAST TWO PERYLENE MONOIMIDE-MONOANHYDRIDES WITH 1,3-PROPANEDIAMINE FORM THE IMIDES; PHOTOCONDUCTIVE IMAGING MEMBERS WITH THE MIXED PERYLENE DIMER PIGMENTS; ENVIRONMENTALLY ACCEPTABLE MIXTURES | XEROX CORPORATION | 2002-10-15 | — | — | US | claimed |
| EP-0861878-B1 | Unsymmetrical perylene dimers | XEROX CORP (US) | 2001-10-24 | — | — | EP | claimed |
| US-6287738-B1 | CONTAINING PERYLENEBISIMIDE | XEROX CORPORATION | 2001-09-11 | — | — | US | claimed |
| EP-0994853-A2 | COMPOUNDS AND METHODS FOR THE INHIBITION OF THE EXPRESSION OF VCAM-1 | Atherogenics, Inc. (US) | 2000-04-26 | — | — | EP | claimed |
| US-5908960-A | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-01 | — | — | US | claimed |
| WO-1998051662-A2 | COMPOUNDS AND METHODS FOR THE INHIBITION OF THE EXPRESSION OF VCAM-1 | ATHEROGENICS, INC. (US) | 1998-11-19 | — | — | WO | claimed |
| EP-0861878-A1 | Unsymmetrical perylene dimers | XEROX CORPORATION (US) | 1998-09-02 | — | — | EP | claimed |
| EP-0826740-A1 | Symmetrical perylene dimers | XEROX CORPORATION (US) | 1998-03-04 | — | — | EP | claimed |
| US-5683842-A | CHARGE GENERATORS FOR IMAGES | XEROX CORPORATION (US) | 1997-11-04 | — | — | US | claimed |
| US-5645965-A | XEROGRAPHY, CHARGE GENERATING COMPOUNDS | XEROX CORPORATION (US) | 1997-07-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054401-A1 | Substituted bicyclic derivatives and use thereof | LTB4R2, LTC4S, LTB4R | ALDH1A1 1731/4885TSHR 1642/4885MAPK1 791/4885 |
| US-20100331299-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | PNLIP, LPL, LIPA | ALDH1A1 364/4885TSHR 2931/4885MAPK1 4496/4885 |
| US-20100048893-A1 | Substituted arylalkanoic acid derivatives and use thereof | CYSLTR1, CYSLTR2, LTB4R2 | ALDH1A1 996/4885TSHR 536/4885MAPK1 1651/4885 |
| US-20090062530-A1 | Substituted arylalkanoic acid derivatives and use thereof | CYSLTR1, CYSLTR2, LTB4R2 | ALDH1A1 996/4885TSHR 536/4885MAPK1 1651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.