Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963674 | 0.86 | POLB (0.55) | XDHHPGDL3MBTL1SMN1; SMN2NR4A3 | |
| SCHEMBL10893230 | 0.85 | MAPK14 (0.53) | PTPN1XDHMEN1KMT2AL3MBTL1 | |
| SCHEMBL10366100 | 0.85 | XDH (0.45) | XDHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL10890676 | 0.85 | RAB9A (0.49) | XDHRAB9ANPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL10897041 | 0.85 | RXRA (0.50) | KMT2ARAB9ANPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL10834339 | 0.85 | RPA1 (0.49) | XDHMEN1KMT2ANPSR1L3MBTL1 | |
| SCHEMBL10892897 | 0.84 | XDH (0.43) | XDHMEN1KMT2AHPGDHSD17B10 | |
| SCHEMBL10368222 | 0.83 | NPC1 (0.47) | MEN1KMT2ARAB9ANPC1L3MBTL1 | |
| SCHEMBL10368106 | 0.83 | KMT2A (0.47) | PTPN1MEN1KMT2AUSP2HPGD | |
| SCHEMBL10896777 | 0.82 | MAPT (0.40) | PTPN1XDHMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4631343-A | Cyanopyrazole intermediates | ELI LILLY AND COMPANY (US) | 1986-12-23 | — | — | US | claimed |
| EP-2227453-B1 | HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | VERTEX PHARMA (US) | 2016-03-09 | — | — | EP | disclosed |
| US-8519137-B2 | Heteroaryl amides useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2227453-A2 | HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009049180-A2 | HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-16 | — | — | WO | disclosed |
| US-20090099233-A1 | HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-04-16 | — | — | US | disclosed |
| EP-1620405-A2 | PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS | Abbott Laboratories (US) | 2006-02-01 | — | — | EP | disclosed |
| US-20050020564-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | ABBOTT LABORATORIES | 2005-01-27 | — | — | US | disclosed |
| WO-2004099154-A2 | PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2004-11-18 | — | — | WO | disclosed |
| US-20040220170-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | ABBOTT LABORATORIES | 2004-11-04 | — | — | US | disclosed |
| EP-0151867-B1 | CYANOPYRAZOLE HERBICIDES | ELI LILLY AND COMPANY (US) | 1990-01-10 | — | — | EP | disclosed |
| US-4631343-A | Cyanopyrazole intermediates | ELI LILLY AND COMPANY (US) | 1986-12-23 | — | — | US | disclosed |
| US-4589905-A | TERRESTRIAL AND AQUATIC APPLICATIONS | ELI LILLY AND COMPANY (US) | 1986-05-20 | — | — | US | disclosed |
| EP-0151867-A2 | Cyanopyrazole herbicides | ELI LILLY AND COMPANY (US) | 1985-08-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099233-A1 | HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | CACNA1B, SCN3A, SCN2A | PTPN1 2224/4885XDH 2386/4885MEN1 2896/4885 |
| US-20050020564-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | SCN3A, KCNN3, TRPV3 | PTPN1 2075/4885XDH 4066/4885MEN1 4304/4885 |
| US-20040220170-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | SCN3A, KCNN3, TRPV3 | PTPN1 2075/4885XDH 4066/4885MEN1 4304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.