Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12189290 | 0.84 | L3MBTL1 (0.60) | SYKALDH1A1AURKBINCENPLMNA | |
| SCHEMBL2087592 | 0.83 | MAOB (0.68) | ALDH1A1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL6955580 | 0.78 | ALDH1A1 (0.61) | ALDH1A1LMNAL3MBTL1RXFP1MEN1 | |
| SCHEMBL9330680 | 0.77 | ALDH1A1 (0.55) | ALDH1A1LMNARXFP1MEN1KMT2A | |
| SCHEMBL13460841 | 0.74 | ABCB1 (0.53) | ALDH1A1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL7865007 | 0.74 | RXRA (0.54) | ALDH1A1LMNAL3MBTL1RXRARXRB | |
| SCHEMBL10783055 | 0.73 | SMN1; SMN2 (0.53) | ALDH1A1LMNAL3MBTL1GAAMAOB | |
| SCHEMBL6959864 | 0.73 | MAPT (0.57) | ALDH1A1LMNAL3MBTL1KMT2AMAOB | |
| SCHEMBL21246919 | 0.73 | PTPRC (0.51) | ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL11448863 | 0.72 | MAPT (0.71) | ALDH1A1LMNAL3MBTL1KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |