Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963530 | 0.91 | HTT (0.44) | HTTKMT2ASMN1; SMN2LMNAGCGR | |
| SCHEMBL6953495 | 0.87 | CNR1 (0.49) | KMT2ASMN1; SMN2GCGRMAPTMAPK1 | |
| SCHEMBL6958370 | 0.85 | ALDH1A1 (0.48) | HTTKMT2ASMN1; SMN2LMNAGCGR | |
| SCHEMBL6964701 | 0.85 | KMT2A (0.43) | HTTKMT2ASMN1; SMN2LMNAGCGR | |
| SCHEMBL8890569 | 0.83 | KMT2A (0.55) | KMT2ASMN1; SMN2LMNAHPGDKDM4E | |
| SCHEMBL6954596 | 0.83 | RAB9A (0.53) | HTTKMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6957950 | 0.82 | LMNA (0.50) | HTTKMT2ASMN1; SMN2LMNAGCGR | |
| SCHEMBL6958429 | 0.81 | POLB (0.45) | HTTKMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6952292 | 0.80 | LMNA (0.53) | KMT2ASMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL6959624 | 0.80 | MPO (0.51) | HTTSMN1; SMN2LMNAGCGRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540143-B1 | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 2003-02-05 | — | — | EP | disclosed |
| US-5714503-A | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 1998-02-03 | — | — | US | disclosed |
| US-5593993-A | VIRICIDES FOR HTLV TREATMENT OF AIDS | MEDIVIR AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993003022-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1993-02-18 | — | — | WO | disclosed |