Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 4/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | F11 | P03951 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 4/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977968 | 1.00 | RIPK1 (0.43) | RIPK1HSD11B1SCD5EPHX2F11 | |
| SCHEMBL6970938 | 0.77 | KMT2A (0.42) | — | |
| SCHEMBL6965742 | 0.74 | RIPK1 (0.44) | RIPK1HSD11B1SCD5EPHX2F11 | |
| SCHEMBL23009636 | 0.70 | RIPK1 (0.49) | RIPK1HSD11B1EPHX2F11HSP90AA1 | |
| SCHEMBL4019469 | 0.68 | RIPK1 (0.62) | RIPK1HSD11B1SCD5EPHX2HSP90AA1 | |
| SCHEMBL1853141 | 0.67 | RIPK1 (0.69) | RIPK1HSD11B1SCD5EPHX2HSP90AA1 | |
| SCHEMBL1847627 | 0.67 | RIPK1 (0.69) | RIPK1HSD11B1SCD5EPHX2HSP90AA1 | |
| SCHEMBL17558248 | 0.67 | RIPK1 (0.69) | RIPK1HSD11B1SCD5EPHX2HSP90AA1 | |
| SCHEMBL23009786 | 0.66 | F11 (0.53) | RIPK1HSD11B1EPHX2F11 | |
| SCHEMBL23009601 | 0.66 | F11 (0.53) | RIPK1HSD11B1EPHX2F11HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023265-B1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM CA LTD (CA) | 2003-01-15 | — | — | EP | disclosed |
| US-6211170-B1 | Azetidinone derivatives for the treatment of HCMV infections | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2001-04-03 | — | — | US | disclosed |