Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968586 | 0.92 | L3MBTL1 (0.36) | ERN1LMNAMAPK1RAB9AFPR2 | |
| SCHEMBL6970169 | 0.92 | L3MBTL1 (0.36) | ERN1LMNAMAPK1RAB9AFPR2 | |
| SCHEMBL6970899 | 0.92 | L3MBTL1 (0.36) | ERN1LMNAMAPK1RAB9AFPR2 | |
| SCHEMBL8567033 | 0.90 | L3MBTL1 (0.40) | ERN1LMNAMAPK1RAB9AFPR2 | |
| SCHEMBL6956392 | 0.90 | CHRM1 (0.34) | ERN1LMNAMAPK1RAB9ACHRM1 | |
| SCHEMBL6958360 | 0.80 | LMNA (0.34) | ERN1LMNAMAPK1RAB9AFPR2 | |
| SCHEMBL12306394 | 0.79 | L3MBTL1 (0.38) | ERN1LMNAMAPK1RAB9AFPR2 | |
| SCHEMBL29249360 | 0.79 | L3MBTL1 (0.35) | ERN1LMNAMAPK1RAB9ACHRM1 | |
| SCHEMBL6963346 | 0.77 | SIGMAR1 (0.33) | CHRM1FAAHMGLL | |
| Bromide SCHEMBL6968332 | 0.77 | FAAH (0.42) | ERN1LMNAMAPK1RAB9ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0849269-B9 | Vinyl pyrrolidine cephalosporins with basic substituents | BASILEA PHARMACEUTICA AG (CH) | 2003-03-05 | — | — | EP | disclosed |
| EP-0849269-B1 | Vinyl pyrrolidine cephalosporins with basic substituents | BASILEA PHARMACEUTICA AG (CH) | 2002-07-10 | — | — | EP | disclosed |
| US-5981519-A | Vinyl-pyrrolidinone cephalosporins | HOFFMAN-LA ROCHE INC. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0849269-A1 | Vinyl pyrrolidine cephalosporins with basic substituents | F. HOFFMANN-LA ROCHE AG (CH) | 1998-06-24 | — | — | EP | disclosed |