SCHEMBL6966973

SCHEMBL6966973

CN(Cc1ccc(Cc2c[nH]cn2)cc1)C(=O)Cc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 1/20 0.50
NPC1 O15118 3/20 0.48
RAB9A P51151 3/20 0.48
SMN1; SMN2 Q16637 2/20 0.45
KMT2A Q03164 2/20 0.45
LTB4R Q15722 3/20 0.42
LTB4R2 Q9NPC1 3/20 0.42
MAPK1 P28482 1/20 0.41
CA12 O43570 1/20 0.41
CA9 Q16790 1/20 0.41
MEN1 O00255 1/20 0.41
ALOX5 P09917 1/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
CDK4 P11802 1/20 0.40
HPGD P15428 1/20 0.40
APOBEC3A P31941 1/20 0.40
TSPO P30536 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6972036 0.89 ALDH1A1 (0.50) ROCK2NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL6974227 0.89 NPC1 (0.44) NPC1RAB9ASMN1; SMN2KMT2ACA12
SCHEMBL9080507 0.84 AOC3 (0.45) ROCK2RAB9AKMT2AMEN1ALOX5
SCHEMBL6960285 0.81 CHRNB2 (0.50) NPC1RAB9ASMN1; SMN2KMT2ACA12
SCHEMBL6961731 0.79 ALDH1A1 (0.49) ROCK2NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL1516137 0.78 NPC1 (0.75) ROCK2NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL6974366 0.78 LTB4R (0.45) RAB9ALTB4RLTB4R2ALDH1A1
SCHEMBL6966618 0.78 ALDH1A1 (0.47) NPC1RAB9ASMN1; SMN2ALDH1A1POLB
SCHEMBL6966335 0.77 CA2 (0.44) KMT2AMEN1ALDH1A1POLBHPGD
SCHEMBL649075 0.77 ALDH1A1 (0.46) RAB9ASMN1; SMN2KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729459-B1 PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS SCHERING CORP (US) 2003-03-12 EP disclosed
US-5578616-A ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS SCHERING CORPORATION (US) 1996-11-26 US disclosed
EP-0729459-A1 PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS SCHERING CORPORATION (US) 1996-09-04 EP disclosed
WO-1995014007-A1 PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS SCHERING CORPORATION (US) 1995-05-26 WO disclosed