Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970199 | 0.90 | RAB9A (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4NPC1 | |
| SCHEMBL9079669 | 0.86 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL7972578 | 0.85 | CHRNB2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL6974227 | 0.84 | NPC1 (0.44) | KMT2ANPC1RAB9ASMN1; SMN2CA12 | |
| SCHEMBL6966973 | 0.81 | ROCK2 (0.50) | KMT2ANPC1RAB9ASMN1; SMN2CA12 | |
| SCHEMBL6972511 | 0.81 | ALOX5 (0.45) | HCAR2 | |
| SCHEMBL7977515 | 0.74 | KMT2A (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL6966618 | 0.73 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6969265 | 0.72 | ALDH1A1 (0.41) | KMT2ANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL649075 | 0.72 | ALDH1A1 (0.46) | KMT2ARAB9ASMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729459-B1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0729459-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014007-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |