SCHEMBL6967032

SCHEMBL6967032

COc1ccc2c(=O)c(C=O)coc2c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 11/20 0.71
MAOB P27338 11/20 0.71
PTGS2 P35354 3/20 0.67
BCHE P06276 1/20 0.64
ALOX5 P09917 1/20 0.64
ALOX15 P16050 1/20 0.64
ACHE P22303 1/20 0.64
NPC1 O15118 2/20 0.58
MAPT P10636 2/20 0.58
RAB9A P51151 2/20 0.58
KDM4E B2RXH2 1/20 0.58
MEN1 O00255 1/20 0.58
ALDH1A1 P00352 1/20 0.58
TP53 P04637 1/20 0.58
CYP3A4 P08684 1/20 0.58
HPGD P15428 1/20 0.58
KMT2A Q03164 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
PTPN1 P18031 2/20 0.57
PTPN2 P17706 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29953101 1.00 MAOA (0.71) MAOAMAOBPTGS2BCHEALOX5
SCHEMBL4803818 0.89 MAOA (0.59) MAOAMAOBPTGS2BCHEALOX5
SCHEMBL1572774 0.88 MAOB (0.71) MAOAMAOBPTGS2BCHEALOX5
SCHEMBL13004141 0.84 ALDH1A1 (0.61) MAOAMAOBPTGS2BCHEALOX5
SCHEMBL13631722 0.84 MAOA (0.58) MAOAMAOBPTGS2BCHEALOX5
SCHEMBL11876946 0.83 MAPT (0.62) MAOAMAOBPTGS2BCHEALOX5
SCHEMBL29955251 0.83 MAPT (0.62) MAOAMAOBPTGS2BCHEALOX5
SCHEMBL29956322 0.80 PTPN1 (0.61) MAOAMAOBPTGS2MAPTKDM4E
SCHEMBL7372448 0.79 PTPN1 (0.51) MAOAMAOBBCHEALOX5ALOX15
SCHEMBL11565649 0.78 RAB9A (0.61) MAOAMAOBPTGS2NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3984441-A ANTIALLERGENS TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) 1976-10-05 US claimed
US-6545031-B1 Carboxyalkenylpyrazolylbenzene derivatives, such as (E)-alpha-((5-(2-((2-carboxyphenyl)methoxy)-4-methoxyphenyl) -1-ethyl-1H-pyrazol-4-yl)methylene)-6-methoxy-1,3-benzodioxole -5-propanoic acid SMITHKLINE BEECHAM CORPORATION 2003-04-08 US disclosed
EP-0841926-B1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-03-26 EP disclosed
EP-0843551-B1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2002-02-06 EP disclosed
US-6174906-B1 TREATMENT OF DISEASES CAUSED BY AN EXCESS OF ENDOTHELIN COMPRISING ADMINISTERING ENDOTHELIN RECEPTOR ANTAGONIST COMPOUND; FOR TREATING UNSTABLE ANGINA, CORONARY VASOSPASM AND MYOCARDIAL SALVAGE, RESTENOSIS, PULMONARY HYPERTENSION SMITHKLINE BEECHAM CORPORATION 2001-01-16 US disclosed
US-6030970-A TREATING RENAL FAILURE OR CEREBROVASCULAR DISEASE, RADIO-CONTRAST INDUCED RENAL FAILURE, CONGESTIVE HEART FAILURE, UNSTABLE ANGINA, CORONARY VASOPASM, MYOCARDIAL SALVAGE, RESTENOSIS, PULMONARY HYPERTENSION, STROKES SMITHKLINE BEECHAM CORPORATION (US) 2000-02-29 US disclosed
EP-0841926-A4 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 1999-08-04 EP disclosed
EP-0843551-A4 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 1998-08-12 EP disclosed
EP-0843551-A1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1998-05-27 EP disclosed
EP-0841926-A1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1998-05-20 EP disclosed
WO-1997004774-A1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-02-13 WO disclosed
WO-1997004773-A1 ENDOTHELIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-02-13 WO disclosed
US-4098799-A ANTIALLERGENS, HYPERACIDITY WARNER-LAMBERT COMPANY (US) 1978-07-04 US disclosed
US-4008252-A ANTIALLERGENS, ANTIHYPERACIDITY WARNER-LAMBERT COMPANY (US) 1977-02-15 US disclosed