Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 5/20 | 0.42 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970836 | 0.77 | PKM (0.40) | MAPTPOLBCRBNSMN1; SMN2ALDH1A1 | |
| SCHEMBL6970142 | 0.74 | CNR2 (0.54) | MAPTACHECNR2CNR1BCHE | |
| SCHEMBL6973625 | 0.73 | ALDH1A1 (0.51) | MAPTPOLBACHECNR2CNR1 | |
| SCHEMBL6973555 | 0.72 | ACHE (0.48) | MAPTPOLBACHECNR2CNR1 | |
| SCHEMBL6967696 | 0.71 | ACHE (0.44) | MAPTACHECNR2CNR1SMN1; SMN2 | |
| SCHEMBL6975193 | 0.71 | CNR2 (0.51) | MAPTACHECNR2CNR1BCHE | |
| SCHEMBL6968101 | 0.70 | CNR2 (0.48) | MAPTACHECNR2CNR1BCHE | |
| SCHEMBL6970884 | 0.70 | CNR2 (0.54) | ACHECNR2CNR1BCHEPIK3R1 | |
| SCHEMBL6977942 | 0.68 | CNR2 (0.44) | MAPTPOLBACHECNR2CNR1 | |
| SCHEMBL8042454 | 0.68 | KCNA5 (0.42) | MAPTPOLBCRBNSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | claimed |