Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 6/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8134750 | 0.83 | AR (0.51) | ARTP53JAK2MAPTHTT | |
| SCHEMBL10649798 | 0.79 | AR (0.48) | ARTP53JAK2MAPTHTT | |
| SCHEMBL9991690 | 0.79 | TRPV1 (0.54) | ARTP53JAK2MAPTHTT | |
| SCHEMBL27401813 | 0.78 | GAA (0.48) | MAPTHTTALDH1A1 | |
| SCHEMBL1405006 | 0.78 | ALDH1A1 (0.51) | ARTP53JAK2MAPTHTT | |
| SCHEMBL12849679 | 0.78 | TRPV1 (0.50) | ARTP53JAK2MAPTHTT | |
| SCHEMBL840362 | 0.77 | ALDH1A1 (0.55) | HTTNPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL5801586 | 0.77 | POLB (0.57) | TP53JAK2MAPTHTTKLK7 | |
| SCHEMBL7299817 | 0.74 | GAA (0.56) | TP53JAK2MAPTHTTKLK7 | |
| SCHEMBL1576313 | 0.74 | PDK1 (0.67) | TP53JAK2MAPTHTTKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849911-A | Antivirally active heterocyclic azahexane derivatives | NOVARTIS FINANCE CORPORATION (US) | 1998-12-15 | — | — | US | disclosed |
| US-5753652-A | Antiretroviral hydrazine derivatives | NOVARTIS CORPORATION (US) | 1998-05-19 | — | — | US | disclosed |