Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 9/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | UBE2M | P61081 | 1/20 | 0.51 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969338 | 0.84 | MGLL (0.48) | LMNAMEN1KMT2AACHE | |
| SCHEMBL6976291 | 0.84 | LMNA (0.55) | LMNAUBE2MDCUN1D1ALDH1A1MEN1 | |
| SCHEMBL6978451 | 0.82 | HSD11B1 (0.53) | MAPK7HSD11B1LMNAALDH1A1MEN1 | |
| SCHEMBL6974760 | 0.78 | MAP3K12 (0.55) | HSD11B1LMNAUBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL6981676 | 0.76 | JUND (0.46) | ALDH1A1MEN1KMT2AACHE | |
| SCHEMBL6976878 | 0.75 | HSD11B1 (0.51) | HSD11B1LMNAUBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL16628716 | 0.73 | HSP90AA1 (0.77) | LMNAALDH1A1KMT2A | |
| SCHEMBL6968387 | 0.73 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2A | |
| SCHEMBL21339703 | 0.73 | MAPK7 (0.83) | MAPK7MEN1KMT2A | |
| SCHEMBL21332392 | 0.73 | MAPK7 (1.00) | MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |